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Literature summary for 3.4.21.73 extracted from

  • Nieves, E.C.; Manchanda, N.
    A cleavage-resistant urokinase plasminogen activator receptor exhibits dysregulated cell-surface clearance (2010), J. Biol. Chem., 285, 12595-12603.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.73

Activating Compound

Activating Compound Comment Organism Structure
additional information u-PAR in binding to u-PA initiates plasminogen activation. A cleavage-resistant u-PAR, cr-u-PAR, exhibits accelerated internalization and resurfacing due to direct association with the endocytic receptor alpha2-macroglobulin receptor/low density lipoprotein receptor-related protein in the absence of the enzyme inhibitor complex of active u-PA and plasminogen activator inhibitor-1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PAI-1
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Homo sapiens u-PA forms a complex with its receptor u-PAR in plasminogen ativation plasmin + ?
-
 ?
urokinase plasminogen activator receptor + H2O Homo sapiens receptor cleavage by u-PA, u-PAR is susceptible to proteolysis by its cognate ligand and several other proteases, biological significance, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification single-chain uPA is cleaved to the activated two-chain form Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell
-
 Homo sapiens
-
U-937 cell lymphoma cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
plasminogen + H2O u-PA forms a complex with its receptor u-PAR in plasminogen ativation Homo sapiens plasmin + ?
-
 ?
urokinase plasminogen activator receptor + H2O receptor cleavage by u-PA, u-PAR is susceptible to proteolysis by its cognate ligand and several other proteases, biological significance, overview Homo sapiens ?
-
 ?
urokinase plasminogen activator receptor + H2O receptor cleavage by u-PA, u-PAR is susceptible to proteolysis by its cognate ligand and several other proteases Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
u-PA
-
 Homo sapiens
Urokinase plasminogen activator
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function urokinase plasminogen activator receptor, u-PAR, binds u-PA and participates in plasminogen activation in addition to modulating several cellular processes such as adhesion, proliferation, and migration Homo sapiens