Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | uPA transcription and activity is only markedly increased during chronic neurodegeneration, not during acute intracerebral lipopolysaccharide-induced or acute kainate-induced neurodegeneration. Increase in total plasminogen activation with progression of prion disease is apparent in both soluble and membrane fractions | Mus musculus |
Cloned (Comment) | Organism |
---|---|
quantitative uPA expression analysis | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
plasminogen activator inhibitor 1 | i.e. PAI-1 | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Mus musculus | - |
plasmin + ? | - |
? | |
plasminogen + H2O | Mus musculus C57BL/6 | - |
plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | from ME7-infected mice | Mus musculus | - |
microglia | - |
Mus musculus | - |
additional information | the uPA receptor, a GPI-linked cell surface protein, occurs in macrophages infiltrating the central nervous system, and in the cerebrospinal fluid during a number of CNS pathologies | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | - |
Mus musculus | plasmin + ? | - |
? | |
plasminogen + H2O | - |
Mus musculus C57BL/6 | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
uPA | - |
Mus musculus |
Urokinase plasminogen activator | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | uPA transcription and activity is only markedly increased during chronic neurodegeneration, not during acute intracerebral lipopolysaccharide-induced or acute kainate-induced neurodegeneration. Increase in total plasminogen activation with progression of prion disease is apparent in both soluble and membrane fractions | up |
General Information | Comment | Organism |
---|---|---|
malfunction | uPA transcription and activity is only markedly increased during chronic neurodegeneration, not during acute intracerebral lipopolysaccharide-induced or acute kainate-induced neurodegeneration. Increase in total plasminogen activation with progression of prion disease is apparent in both soluble and membrane fractions | Mus musculus |
metabolism | involvement of the uPAR/uPA system in CNS function and pathology, overview | Mus musculus |