Literature summary for 3.4.21.73 extracted from

Yang, H.; Choi, H.J.; Park, S.H.; Kim, J.S.; Moon, Y.
Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells (2009), Biochem. Pharmacol., 78, 1205-1213.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colon carcinoma cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PLAU	-	Homo sapiens
urokine-type plasminogen activator	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	macrophage inhibitory cytokine-1, MIC-1, is a critical inducer of apoptosis-related gene products such as activated urokinetype plasminogen activator, PLAU, and PLAU receptor, uPAR. Ribotoxic stress agent anisomycin induces MIC-1 gene expression. Gene expression of apoptosis-mediator MIC-1 is enhanced by activating transcription factor 3, ATF-3, via the p38 MAP kinase signaling pathway, and both promoter activity and mRNA stability of MIC-1 gene are up-regulated by ribotoxic anisomycin via the p38 MAP kinase signaling pathway	up

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Release 2023.1 (January 2023)