Literature summary for 3.4.21.73 extracted from

Lund, I.K.; Joegi, A.; Rono, B.; Rasch, M.G.; Lund, L.R.; Almholt, K.; Gardsvoll, H.; Behrendt, N.; Romer, J.; Hoyer-Hansen, G.
Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo (2008), J. Biol. Chem., 283, 32506-32515.

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Inhibitors

Inhibitors	Comment	Organism	Structure
monoclonal antibody mU1	murine monoclonal antibody directed against murine uPA. mU1 blocks uPA-catalyzed plasminogen activation in vitro, as well as plasmin-mediated pro-uPA activation. Systemic administration of mU1 rescues mice treated with a uPA-activable anthrax protoxi and impairs uPA-mediated hepatic fibrinolysis in tissue-type plasminogen activator-deficient mice, resulting in a phenotype mimicking that of uPA/tPA double deficient mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

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Release 2023.1 (January 2023)