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Literature summary for 3.4.21.73 extracted from

  • Tarui, T.; Akakura, N.; Majumdar, M.; Andronicos, N.; Takagi, J.; Mazar, A.P.; Bdeir, K.; Kuo, A.; Yarovoi, S.V.; Cines, D.B.; Takada, Y.
    Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation (2006), Thromb. Haemost., 95, 524-534.
    View publication on PubMed
Search for more literature for 3.4.21.73

Activating Compound

Activating Compound Comment Organism Structure
integrin alpha v beta3 binds specifically to the enzyme and is required for plasminogen activation, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
EDTA inhibits binding of integrin alphanybeta3 to the enzyme Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Mus musculus the enzyme is responsible for plasminogen activation, it is also involved in cell adhesion, chemotaxis, and proliferation, the signaling events are not mediated by uPA receptor uPAR/CD87, but require the kringle domain of the enzyme, which binds integrin alphanybeta3 for induction of cell migration, e.g. of CHO cells, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information recombinant uPA binds purified soluble human integrin alphanybeta3, overview Mus musculus ?
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 ?
plasminogen + H2O
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 Mus musculus ?
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 ?
plasminogen + H2O the enzyme is responsible for plasminogen activation, it is also involved in cell adhesion, chemotaxis, and proliferation, the signaling events are not mediated by uPA receptor uPAR/CD87, but require the kringle domain of the enzyme, which binds integrin alphanybeta3 for induction of cell migration, e.g. of CHO cells, overview Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
uPA
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 Mus musculus
Urokinase-type plasminogen activator
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 Mus musculus