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Literature summary for 3.4.21.73 extracted from
- Maspin binds to urokinase-type and tissue-type plasminogen activator through exosite-exosite interactions (2007), J. Biol. Chem., 282, 19502-19509.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R340A | site-directed mutagenesis, the binding of the mutant enzyme to maspin is not affected | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| maspin | regulates uPA-dependent processes in vivo not involving its RCL sequence with Arg340, but is inable to directly inhibit uPA catalytic activity in vitro, binds the enzyme in both singlechain and double-chain forms, maspin is a member of the serpin family with a reactive center loop that is incompatible with proteinase inhibition by the serpin conformational change mechanism, overview | Homo sapiens |  |
| plasminogen activator inhibitor-1 | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Urokinase-type plasminogen activator | - |
Homo sapiens |
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