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Literature summary for 3.4.21.73 extracted from

  • Sasajima, M.; Moriwaki, S.; Hotta, M.; Kitahara, T.; Takema, Y.
    trans-3,4-Dimethyl-3-hydroxyflavanone, a hair growth enhancing active component, decreases active transforming growth factor beta2 (TGF-beta2) through control of urokinase-type plasminogen activator (uPA) on the surface of keratinocytes (2008), Biol. Pharm. Bull., 31, 449-453.
    View publication on PubMed
Search for more literature for 3.4.21.73

Inhibitors

Inhibitors Comment Organism Structure
trans-3,4'-dimethyl-3-hydroxyflavanone i.e. t-flavanone, a synthetic compound with hair growth enhancing activity that is effective against male pattern alopecia, inhibits the enzyme on the surface of keratinocytes, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface on keratinocytes Homo sapiens 9986
-
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens trans-3,4-dimethyl-3-hydroxyflavanone, a hair growth enhancing active component, decreases active transforming growth factor beta2 and the TGF-b 2 activation cascade through control of uPA on the surface of keratinocytes, mechanism, overview ?
-
 ?
plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte cell surface Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information trans-3,4-dimethyl-3-hydroxyflavanone, a hair growth enhancing active component, decreases active transforming growth factor beta2 and the TGF-b 2 activation cascade through control of uPA on the surface of keratinocytes, mechanism, overview Homo sapiens ?
-
 ?
plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
plasminogen + H2O human plasminogen Homo sapiens plasmin + ?
-
 ?
t-butyloxycarbonyl-valyl-leucyl-lysine-4-methylcoumaryl-7-amide + H2O
-
 Homo sapiens Boc-L-Val-L-Leu-L-Lys + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
uPA
-
 Homo sapiens
Urokinase-type plasminogen activator
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens