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Literature summary for 3.4.21.73 extracted from

  • Joossens, J.; Van der Veken, P.; Lambeir, A.M.; Augustyns, K.; Haemers, A.
    Development of irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator (2004), J. Med. Chem., 47, 2411-2413.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
diphenyl (N-benzyloxycarbonyl-D-seryl-L-alanyl)amino-(3-guanylpropyl)methanephosphonate 50% inhibition at 0.000061 mM Homo sapiens
diphenyl (N-benzyloxycarbonyl-D-seryl-L-alanyl)amino-(4-guanylbutyl)methanephosphonate 50% inhibition at 0.00025 mM Homo sapiens
diphenyl (N-benzyloxycarbonyl-D-seryl-L-alanyl)amino-(4-guanylphenyl)methanephosphonate 50% inhibition at 0.0016 mM Homo sapiens
diphenyl 1-(N-benzyloxycarbonyl-D-seryl-L-alanyl)amino-2-(4-guanylphenyl)ethanephosphonate 50% inhibition at 0.000057 mM Homo sapiens
trans-diphenyl N-(N-benzyloxycarbonyl-D-seryl-L-alanyl)amino-(4-(guanylmethyl)-cyclohexyl)methanephosphonate 50% inhibition at 0.0011 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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commercial preparation from Sigma Aldrich
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-pyroGlu-Gly-L-Arg-4-nitroanilide + H2O i.e. S-2444 Homo sapiens L-pyroGlu-Gly-L-Arg + 4-nitroaniline
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