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Literature summary for 3.4.21.73 extracted from

  • Madsen, M.A.; Deryugina, E.I.; Niessen, S.; Cravatt, B.F.; Quigley, J.P.
    Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation (2006), J. Biol. Chem., 281, 15997-16005.
    View publication on PubMed

Application

Application Comment Organism
medicine active enzyme promotes tumor progression, activation of enzyme appears as a key step in tumor progression. Inhibition of enzyme with natural or synthetic inhibitors diminishes high intravasating Matrigel invasion in vitro and intravasation and metastasis in vivo Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens active enzyme promotes tumor progression, activation of enzyme appears as a key step in tumor progression ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HT-1080 cell fibrosarcoma cell line Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information active enzyme promotes tumor progression, activation of enzyme appears as a key step in tumor progression Homo sapiens ?
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?