Application | Comment | Organism |
---|---|---|
medicine | treatment of cancer with small-molecule active-site inhibitors with a C-terminal 4-amindinobenzylamide residue to prevent metastasis. Inhibitor dose of 2 x 1.5 mg/kg/day of inhibitor N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)-L-serinamide reduces number of metastases to 4.6% in mice | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
in complex with inhibitor N-[(4-chlorobenzyl)sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)-L-alaninamide, N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)-L-serinamide and N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)glycinamide | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)-L-alaninamide | comparison of specificity with five additional trypsin-like serine-proteases | Homo sapiens | |
N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)-L-prolinamide | comparison of specificity with five additional trypsin-like serine-proteases | Homo sapiens | |
N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)-L-serinamide | comparison of specificity with five additional trypsin-like serine-proteases | Homo sapiens | |
N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)glycinamide | comparison of specificity with five additional trypsin-like serine-proteases | Homo sapiens | |
N-[(4-aminobenzyl)sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)glycinamide | comparison of specificity with five additional trypsin-like serine-proteases | Homo sapiens | |
N-[(4-chlorobenzyl)sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)-L-alaninamide | comparison of specificity with five additional trypsin-like serine-proteases | Homo sapiens | |
N-[(4-chlorobenzyl)sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)-L-serinamide | comparison of specificity with five additional trypsin-like serine-proteases | Homo sapiens | |
N-[(4-methylbenzyl)sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)-L-alaninamide | comparison of specificity with five additional trypsin-like serine-proteases | Homo sapiens | |
N-[(4-nitrobenzyl)sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)glycinamide | comparison of specificity with five additional trypsin-like serine-proteases | Homo sapiens | |
N-[[4-(methoxycarbonyl)benzyl]sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)-L-alaninamide | comparison of specificity with five additional trypsin-like serine-proteases | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00749 | - |
- |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0076 | - |
N-[(4-chlorobenzyl)sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)-L-alaninamide | - |
Homo sapiens | |
0.0077 | - |
N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)-L-alaninamide | - |
Homo sapiens | |
0.01 | - |
N-[(4-methylbenzyl)sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)-L-alaninamide | - |
Homo sapiens | |
0.013 | - |
N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)-L-prolinamide | - |
Homo sapiens | |
0.018 | - |
N-[(4-aminobenzyl)sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)glycinamide | - |
Homo sapiens | |
0.018 | - |
N-[[4-(methoxycarbonyl)benzyl]sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)-L-alaninamide | - |
Homo sapiens | |
0.02 | - |
N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)-L-serinamide | - |
Homo sapiens | |
0.023 | - |
N-[(4-chlorobenzyl)sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)-L-serinamide | - |
Homo sapiens | |
0.024 | - |
N-[(4-nitrobenzyl)sulfonyl]-D-seryl-N-(4-carbamimidoylbenzyl)glycinamide | - |
Homo sapiens | |
0.036 | - |
N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)glycinamide | - |
Homo sapiens |