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Literature summary for 3.4.21.73 extracted from
- Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin (1995), J. Biol. Chem., 270, 12250-12256.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ecotin | inhibits uPA almost 10000-fold less efficiently than trypsin, ecotin is expressed on the surface of filamentous bacteriophage, each of the selected ecotin variants (M84R, M84K, M84R/M85R and M84R/M85K) exhibits increased affinity for uPA when compared to wild-type ecotin, with ecotin M84R/M85R showing 2800-fold increase in binding affinity | Homo sapiens | |
| Trypsin | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
commercial preparation of low-molecular weight uPA from American Diagnostica | - |
| Mammalia | - |
commercial preparation of low-molecular weight uPA from American Diagnostica | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? |  |
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