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Literature summary for 3.4.21.69 extracted from

  • Maehata, Y.; Miyagawa, S.; Sawa, Y.
    Activated protein C has a protective effect against myocardial I/R injury by improvement of endothelial function and activation of AKT1 (2012), PLoS ONE, 7, e38738.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Rattus norvegicus Sprague-Dawley
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Source Tissue

Source Tissue Comment Organism Textmining
heart
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Rattus norvegicus
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Synonyms

Synonyms Comment Organism
Activated protein C
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Rattus norvegicus
APC
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Rattus norvegicus

General Information

General Information Comment Organism
physiological function activated protein C has a protective efficacy against ischemia-reperfusion injury in several organs, e.g. in myocardium, possible mechanism, overview. The enzyme improves ischemia-reperfusion injury in spinal cord as neuroprotective effect through insulin like growth factor and AKT1 cascade. AKT1 is one of signals that prevent from heart failure Rattus norvegicus