Application | Comment | Organism |
---|---|---|
medicine | possible therapeutic applications of the enzyme mutant G216D, that has no catalytic activity but retains its antiseptic function without anticoagulant side effects | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G216D | a naturally occuring mutation, the mutant shows impaired protease activity, while preserving the overall protein fold. Superposition of the integrin binding motifs in wild-type and mutant forms suggests that the interaction with integrin can still occur and thus the mutant is likely to retain its antiseptic function related to the neutrophyl integrin binding | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | naturally occuring mutation G216D in the specificity pocket of the enzyme causes protein C deficiency. Superposition of the integrin binding motifs in wild-type and mutant forms suggests that the interaction with integrin can still occur and thus the mutant is likely to retain its antiseptic function related to the neutrophyl integrin binding | Homo sapiens |
additional information | molecular model of the complex of APC with alphaVbeta3 integrin obtained by protein-protein docking approach, molecular dynamics and docking simulation of natural mutant G216D of activated protein C with impaired protease activity, implications for integrin-mediated antiseptic function, overview | Homo sapiens |
physiological function | the enzyme has anticoagulant function in the coagulation system counteracting apoptosis and inflammation in cells. the antiseptic activity of the enzyme is mediated by its binding to leukkocyte integrins, the integrin-binding motif of the enzyme locates at the N-terminus of the catalytic chain | Homo sapiens |