Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.69 extracted from

  • Xue, M.; Dervish, S.; Harrison, L.C.; Fulcher, G.; Jackson, C.J.
    Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice (2012), J. Biol. Chem., 287, 16356-16364.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
Activated protein C
-
Homo sapiens
APC
-
Homo sapiens

General Information

General Information Comment Organism
physiological function activated protein C is a natural anticoagulant with strong cyto-protective and anti-inflammatory properties and inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes when regularly injected into non-obese diabetic BALB/c mice, islets of which exhibit markedly increased expression of insulin, aPC/protein C, endothelial protein C receptor, and matrix metalloproteinase-2. Culture of non-obese diabetic mouse spleen cells with the recombinant human enzyme reduces the secretion of inflammatory cytokines interleukin-1beta and interferon-beta1 but increases interleukin-2 and transforming growth factor-beta1, two cytokines required for Treg differentiation, overview Homo sapiens