Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | activated protein C is a natural anticoagulant with strong cyto-protective and anti-inflammatory properties and inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes when regularly injected into non-obese diabetic BALB/c mice, islets of which exhibit markedly increased expression of insulin, aPC/protein C, endothelial protein C receptor, and matrix metalloproteinase-2. Culture of non-obese diabetic mouse spleen cells with the recombinant human enzyme reduces the secretion of inflammatory cytokines interleukin-1beta and interferon-beta1 but increases interleukin-2 and transforming growth factor-beta1, two cytokines required for Treg differentiation, overview | Homo sapiens |