Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MG-63 cell | - |
Homo sapiens | - |
osteoblastoma cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the activated protein C plays a central role in physiological anticoagulation, and has potent anti-inflammatory mediator and cytoprotective properties. Activated protein C is a cytoprotective anticoagulant that can promote cutaneous healing. The enzyme favorably regulates MG63 viability and differentiation toward bone growth. Bisphosphonates alendronate, zoledronate or pamidronate induce MG-63 cell death in a dose- and time-dependent manner. Pamidronate- and zoledronate-related cell death is prevented by the enzyme treatment, but cell death induced by alendronate is accelerated by the enzyme. The enzyme induces MG-63 cell differentiation that is enhanced by alendronate, but inhibited by pamidronate or zoledronate. Endothelial protein C receptor is expressed by MG-63 cells and mediates the protective effect of the enzyme on zoledronate-induced viability. Expression of type 1 collagen and endothelial protein C receptor is induced by activated protein C treatment in MG-63 cells | Homo sapiens |