Application | Comment | Organism |
---|---|---|
medicine | the enzyme might have therappeutic potential in treatment of Alzheimer's disease | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | inactive enzyme | Homo sapiens | 9986 | - |
extracellular | active enzyme | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | inactive plasma zymogen protein C is activated by proteolysis through the thrombin-thrmbomdulin complex on the vascular endothelial cell surface | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
endothelial cell | inactive enzyme | Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | activated protein C is an important factor in the anticoagulant system. It also regulates amyloid beta secretion by shifting amyloid beta precursor protein processing from the amyloidogenic pathway toward the nonamyloidogenic pathway. ADAM-10 expression is increased by the enzyme and inhibits amyloid beta secretion by stimulating activity of alpha-secretase, expression of presenilin-1 is not influenced by the enzyme in SH-SY5Ycells | Homo sapiens |