Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | lower concentrations of APC, 300-30000 ng/ml, show a cell-protective effect against hypoxia in vitro, whereas higher concentrations of about 0.120 mg/ml demonstrate cytotoxicity in both RPE and photoreceptor cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
commercial preparation | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | lower concentrations of APC, 300-30000 ng/ml, show a cell-protective effect against hypoxia in vitro, whereas higher concentrations of about 0.120 mg/ml demonstrate cytotoxicity in both RPE and photoreceptor cells | Homo sapiens | ? | - |
? | |
additional information | CRVO-induced retinal cell apoptosis is reduced dramatically by intravitreal injection of APC | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | APC inhibits activation of caspase-3, -8, and -9 by hypoxia | Homo sapiens |