Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.69 extracted from

  • Du, Z.J.; Yamamoto, T.; Ueda, T.; Suzuki, M.; Tano, Y.; Kamei, M.
    Activated protein C rescues the retina from ischemia-induced cell death (2011), Invest. Ophthalmol. Vis. Sci., 52, 987-993.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens lower concentrations of APC, 300-30000 ng/ml, show a cell-protective effect against hypoxia in vitro, whereas higher concentrations of about 0.120 mg/ml demonstrate cytotoxicity in both RPE and photoreceptor cells ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-
commercial preparation
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information lower concentrations of APC, 300-30000 ng/ml, show a cell-protective effect against hypoxia in vitro, whereas higher concentrations of about 0.120 mg/ml demonstrate cytotoxicity in both RPE and photoreceptor cells Homo sapiens ?
-
?
additional information CRVO-induced retinal cell apoptosis is reduced dramatically by intravitreal injection of APC Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Activated protein C
-
Homo sapiens
APC
-
Homo sapiens

General Information

General Information Comment Organism
physiological function APC inhibits activation of caspase-3, -8, and -9 by hypoxia Homo sapiens