Literature summary for 3.4.21.69 extracted from

Seol, J.W.; Lee, Y.J.; Jackson, C.J.; Sambrook, P.N.; Park, S.Y.
Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-kappaB pathways (2011), Int. J. Mol. Med., 27, 835-840.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	human umbilical vein endothelial cells, HUVEC	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Activated protein C	-	Homo sapiens
APC	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-kappaB pathways, protective effects and mechanism, overview. APC inhibits induction of cell death by alendronate, zoledronate, and pamidronate, and diminishes activation of caspase-3 by the bisphosphonates	Homo sapiens

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Release 2023.1 (January 2023)