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Literature summary for 3.4.21.69 extracted from
- Activated protein C inhibits high mobility group box 1 signaling in endothelial cells (2011), Blood, 118, 3952-3959.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | activated protein C is approved by the Food and Drug Administration as drug for severe sepsis | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | a thrombin derivative containing the Gla-domain of APC recapitulates all protective effects of APC with a 20 to 50fold higher efficacy | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Activated protein C | - |
Homo sapiens |
| APC | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | activated protein C inhibits high mobility group box 1 signaling in endothelial cells, protective effects of APC are mediated through endothelial cell protein C receptor and protease-activated receptor 1, PAR-1. APC potently inhibits the release of HMGB1, downregulates the expression of HMGB1 receptors, and downregulates the adhesion of the monocytic cell line, THP-1, to HMGB1-activated endothelial cells, and it also down-regulates the cell surface expression of all 3 HMGB1 receptors in endothelial cells | Homo sapiens |
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