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Literature summary for 3.4.21.69 extracted from

  • Sharma, G.R.; Gerlitz, B.; Berg, D.T.; Cramer, M.S.; Jakubowski, J.A.; Galbreath, E.J.; Heuer, J.G.; Grinnell, B.W.
    Activated protein C modulates chemokine response and tissue injury in experimental sepsis (2008), Adv. Exp. Med. Biol., 614, 83-91.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in AV12-664 cells, activation with rat thrombomodulin/bovine thrombin complex Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the protein C pathway plays an important role in vascular function, and acquired deficiency during sepsis is associated with increased organ damage and dysfunction, and mortality, cecal ligation and puncture model, overview, activated protein C acts as feedback inhibitor of thrombin production and has receptor-mediated anti-inflammatory and cytoprotective effects, treatment with activated protein C results in suppression of cytokine response and improved organ function ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification in thrombotic stress, the protein C zymogen is converted to its active form by thrombin in complex with endothelial surface thrombomodulin Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
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 Rattus norvegicus
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liver
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 Rattus norvegicus
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lung
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the protein C pathway plays an important role in vascular function, and acquired deficiency during sepsis is associated with increased organ damage and dysfunction, and mortality, cecal ligation and puncture model, overview, activated protein C acts as feedback inhibitor of thrombin production and has receptor-mediated anti-inflammatory and cytoprotective effects, treatment with activated protein C results in suppression of cytokine response and improved organ function Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
Activated protein C
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 Rattus norvegicus