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Literature summary for 3.4.21.69 extracted from

  • Sun, Y.H.; Tran, S.; Norstrom, E.A.; Dahlbaeck, B.
    Enhanced rate of cleavage at Arg-306 and Arg-506 in coagulation factor Va by Gla domain-mutated human-activated protein C (2004), J. Biol. Chem., 279, 47528-47535.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information enzyme variant with seven point-mutations in Gla domain, enhanced affinity for negatively charged phospholipid and increased anticoagulantic potential. Degradation of Factor Va yields similar fragments from wild-type and mutant, mutant is more efficient in absence and presence of protein S Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Factor Va + H2O hydrolysis at Arg506 and Arg 306 Homo sapiens ?
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