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Literature summary for 3.4.21.69 extracted from

  • Fernandez, J.A.; Petaja, J.; Griffin, J.H.
    Dermatan sulfate and LMW heparin enhance the anticoagulant action of activated protein C (1999), Thromb. Haemost., 82, 1462-1468.
    View publication on PubMed
Search for more literature for 3.4.21.69

Activating Compound

Activating Compound Comment Organism Structure
certoparin clinical LMWH enhances activity Homo sapiens
dalteparin clinical LMWH enhances activity Homo sapiens
dermatan sulfate shows potent APC enhancing effect Homo sapiens
enoxaparin clinical LMWH enhances activity Homo sapiens
glycosaminoglycan enhances activity with factor V but not with factor Va as substrate Homo sapiens
LMW heparin enhances the anticoagulant action of activated protein C Homo sapiens
nadroparin clinical LMWH enhances activity Homo sapiens
tinzaparin clinical LMWH enhances activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor V + H2O Homo sapiens proteolytic inactivation ?
-
 ?
factor VIII + H2O Homo sapiens proteolytic inactivation ?
-
 ?
Factor VIIIa + H2O Homo sapiens #> ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor V + H2O proteolytic inactivation Homo sapiens ?
-
 ?
factor VIII + H2O proteolytic inactivation Homo sapiens ?
-
 ?
Factor VIIIa + H2O proteolytic inactivation Homo sapiens ?
-
 ?
Factor VIIIa + H2O #> Homo sapiens ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
chondroitin sulfate anticoagulant cofactor for APC Homo sapiens
dermatan sulfate anticoagulant cofactor for APC, important physiological cofactor Homo sapiens
heparan sulfate anticoagulant cofactor for APC Homo sapiens