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Literature summary for 3.4.21.69 extracted from

  • He, X.; Rezaie, A.R.
    Identification and characterization of the sodium-binding site of activated protein C (1999), J. Biol. Chem., 274, 4970-4976.
    View publication on PubMed
Search for more literature for 3.4.21.69

Cloned(Commentary)

Cloned (Comment) Organism
expression of Gla domainless Protein C GDPC andGDPC E80K by the RSV-PL4 expression/purification vector system in human 293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E80K GDPC derivative Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for optimal activity Homo sapiens
Na+ required for optimal activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Factor VIIIa + H2O Homo sapiens protein C anticoagulanat pathway, multi-domain vitamin K-dependent plasma serine protease zymogen, down-regulates the blood coagulation cascade upon activation by the thrombin-TM complex by selectively inactivating factors Va and VIII a ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Val-Arg-p-nitroanilide + H2O i.e. S-S2266 Homo sapiens ?
-
 ?
Factor Va + H2O protein C anticoagulanat pathway, multi-domain vitamin K-dependent plasma serine protease zymogen, down-regulates the blood coagulation cascade upon activation by the thrombin-TM complex by selectively inactivating factors Va and VIII a Homo sapiens ?
-
 ?
Factor VIIIa + H2O protein C anticoagulanat pathway, multi-domain vitamin K-dependent plasma serine protease zymogen, down-regulates the blood coagulation cascade upon activation by the thrombin-TM complex by selectively inactivating factors Va and VIII a Homo sapiens ?
-
 ?