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Literature summary for 3.4.21.68 extracted from

  • Ng, K.S.; Leung, H.W.; Wong, P.T.; Low, C.M.
    Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor (2012), J. Biol. Chem., 287, 25520-25529.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme-mediated degradation of NR2B is plasmin-independent Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition of cleavage of the N-methyl-D-aspartate receptor NR2B domain by alpha2-antiplasmin, but by a commercial tissue plasminogen activator inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme can be released into the extracellular space upon depolarizing stimulation Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Homo sapiens activation plasmin + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00750
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala
-
Homo sapiens
-
brain
-
Homo sapiens
-
cerebellum
-
Homo sapiens
-
cerebral cortex
-
Homo sapiens
-
glial cell
-
Homo sapiens
-
hippocampus
-
Homo sapiens
-
hypothalamus
-
Homo sapiens
-
microglia
-
Homo sapiens
-
neuron
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methylsulfonyl-D-cyclohexyltyrosyl-glycyl-arginine-p-nitroanilide + H2O a chromogenic substrate Homo sapiens methylsulfonyl-D-cyclohexyltyrosyl-glycyl-arginine + p-nitroaniline
-
?
N-methyl-D-aspartate receptor + H2O usage of total rat brain lysates or MBP-ATD2B fusion proteins, the recombinant human enzyme shows cleavage of the ATD sequence in the NR2B subunit N-terminus of N-methyl-D-aspartate (NMDA) receptor. Enzyme-mediated degradation of NR2B is plasmin-independent. The enzyme cleaves the MBP-ATD2B fusion protein Homo sapiens ? an Arg27-Arg67-truncated NR2B-containing NMDA receptor might be formed ?
plasminogen + H2O activation Homo sapiens plasmin + ?
-
?

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
Homo sapiens
tPA
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme may directly interact with NR2B subunits of N-methyl-D-aspartate receptors leading to a change in pharmacological properties of NR2B-containing NMDA receptors Homo sapiens