Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Mus musculus | - |
plasmin + ? | - |
? | |
plasminogen + H2O | Mus musculus C57BL/6 | - |
plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus C57BL/6 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Mus musculus | - |
brain | - |
Mus musculus | - |
additional information | tPA colocalizes with neuronal marker MAP2, astrocytic marker glial fibrillary acidic protein, microglial marker isolectin IB4, or endothelial marker von Willebrand factor, overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
casein + H2O | - |
Mus musculus | ? | - |
? | |
casein + H2O | - |
Mus musculus C57BL/6 | ? | - |
? | |
plasminogen + H2O | - |
Mus musculus | plasmin + ? | - |
? | |
plasminogen + H2O | - |
Mus musculus C57BL/6 | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tissue plasminogen activator | - |
Mus musculus |
tPA | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | tissue plasminogen activator, tPA, is the primary source of plasminogen activator in the brain, and is a member of the fibrinolytic system and a serine protease that converts the zymogen plasminogen into the active protease plasmin, and thus cleaves fibrin and dissolves newly formed clots. Bone marrow stromal cells significantly improve functional recovery from stroke dependent on tPA function, overview. In tPA knockout mice, no bone marrow stromal cell effect is observed on functional recovery | Mus musculus |