Application | Comment | Organism |
---|---|---|
medicine | putative interaction and cleavage of NR1 subunit of N-methyl-D-aspartate receptors by a tPA-dependent mechanism can be a relevant therapeutic target for stroke treatment in humans | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-methyl-D-aspartate receptor NR1 subunit + H2O | Mus musculus | - |
? | - |
? | |
N-methyl-D-aspartate receptor NR1 subunit + H2O | Mus musculus Swiss | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus Swiss | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-methyl-D-aspartate receptor NR1 subunit + H2O | - |
Mus musculus | ? | - |
? | |
N-methyl-D-aspartate receptor NR1 subunit + H2O | - |
Mus musculus Swiss | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tissue plasminogen activator | - |
Mus musculus |
tPA | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | tPA potentiates excitotoxicity by interacting with and cleaving the N-terminal end of the NR1 subunit of N-methyl-D-aspartate receptors, leading to an increased calcium influx, Erk1/2 activation, and neurotoxicity, mechanism, overview | Mus musculus |