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Literature summary for 3.4.21.68 extracted from

  • Macrez, R.; Bezin, L.; Le Mauff, B.; Ali, C.; Vivien, D.
    Functional occurrence of the interaction of tissue plasminogen activator with the NR1 subunit of N-methyl-D-aspartate receptors during stroke (2010), Stroke, 41, 2950-2955.
    View publication on PubMed
Search for more literature for 3.4.21.68

Application

Application Comment Organism
medicine putative interaction and cleavage of NR1 subunit of N-methyl-D-aspartate receptors by a tPA-dependent mechanism can be a relevant therapeutic target for stroke treatment in humans Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-methyl-D-aspartate receptor NR1 subunit + H2O Mus musculus
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 ?
-
 ?
N-methyl-D-aspartate receptor NR1 subunit + H2O Mus musculus Swiss
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 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-
Mus musculus Swiss
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-methyl-D-aspartate receptor NR1 subunit + H2O
-
 Mus musculus ?
-
 ?
N-methyl-D-aspartate receptor NR1 subunit + H2O
-
 Mus musculus Swiss ?
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 ?

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
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 Mus musculus
tPA
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 Mus musculus

General Information

General Information Comment Organism
physiological function tPA potentiates excitotoxicity by interacting with and cleaving the N-terminal end of the NR1 subunit of N-methyl-D-aspartate receptors, leading to an increased calcium influx, Erk1/2 activation, and neurotoxicity, mechanism, overview Mus musculus