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Literature summary for 3.4.21.68 extracted from

  • Kim, J.W.; Lee, S.H.; Ko, H.M.; Kwon, K.J.; Cho, K.S.; Choi, C.S.; Park, J.H.; Kim, H.Y.; Lee, J.; Han, S.H.; Ignarro, L.J.; Cheong, J.H.; Kim, W.K.; Shin, C.Y.
    Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: Essential role of astrocyte-derived plasminogen activator inhibitor-1 (2011), Neurochem. Int., 58, 423-433.
    View publication on PubMed
Search for more literature for 3.4.21.68

Inhibitors

Inhibitors Comment Organism Structure
plasminogen activator inhibitor-1 PAI-1, astrocyte-derived, induction of PAI-1 by lipopolysaccharide stimulation in astrocytes Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular tPA activity in both the cellular extract and the supernatant of cultured astrocytes Rattus norvegicus
-
-
intracellular tPA activity in both the cellular extract and the supernatant of cultured astrocytes Rattus norvegicus 5622
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague-Dawley
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glial cell primary culture Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
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neuron primary culture Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 tPA and PAI-1 activities in neural cells, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O casein zymography assay Rattus norvegicus ?
-
 ?
casein + H2O casein zymography assay Rattus norvegicus Sprague-Dawley ?
-
 ?

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
 Rattus norvegicus
tPA
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function regulatory mechanism of the plasminogen activator system in astrocytes, overview Rattus norvegicus