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Literature summary for 3.4.21.68 extracted from

  • Emmetsberger, J.; Mirrione, M.M.; Zhou, C.; Fernandez-Monreal, M.; Siddiq, M.M.; Ji, K.; Tsirka, S.E.
    Tissue plasminogen activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4 (2010), J. Neurosci., 30, 6538-6547.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.68

Protein Variants

Protein Variants Comment Organism
S481A catalytically inactive tPA mutant Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus ZIP4 physically interacts with tPA, immunohistochemic analysis, overview ?
-
 ?
additional information Mus musculus C57BL/6 ZIP4 physically interacts with tPA, immunohistochemic analysis, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Mus musculus
-
neuron primary hippocampal neuronal cultures Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ZIP4 physically interacts with tPA, immunohistochemic analysis, overview Mus musculus ?
-
 ?
additional information ZIP4 physically interacts with tPA, immunohistochemic analysis, overview Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
 Mus musculus
tPA
-
 Mus musculus

General Information

General Information Comment Organism
physiological function tissue plasminogen activator is a secreted serine protease and is also proepileptic and excitotoxic. Wild-type tPA and S481A catalytically inactive tPA mutant mediate zinc uptake via the zinc influx transporter, ZIP4, overview. ZIP4 is upregulated after excitotoxin stimulation of the mouse, male and female, hippocampus. ZIP4 physically interacts with tPA, correlating with an increased intracellular zinc influx and lysosomal sequestration. This sequestration might result in neuroprotection. tPA mutants with deletion of the second kringle domain, DELTAK2, or deletion of the growth factor domain, DELTAGF, are less effective Mus musculus