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Literature summary for 3.4.21.68 extracted from
- Adenosine potentiates human lung mast cell tissue plasminogen activator activity (2011), J. Immunol., 186, 1209-1217.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| adenosine | potentiates mast cell tPA activity and tPA gene expression, abolished in the presence of adenosine deaminase | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HMC-1 cell | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| mast cell | from lung | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Tissue plasminogen activator | - |
Homo sapiens |
| tPA | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | adenosine potentiates mast cell tPA activity and tPA gene expression, abolished in the presence of adenosine deaminase. Adenosine upregulates A2A receptor subtype transcript-expression level in HMC-1 cells and human lung mast cells | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | tPA shows fibrinolytic activity and is used for fibrin clot-lysis | Homo sapiens |
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