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Literature summary for 3.4.21.68 extracted from

  • Baron, A.; Hommet, Y.; Casse, F.; Vivien, D.
    Tissue-type plasminogen activator induces plasmin-dependent proteolysis of intracellular neuronal nitric oxide synthase (2010), Biol. Cell, 102, 539-547.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Mus musculus
-
plasmin + ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron primary cultures of mature cortical neurons Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
Mus musculus plasmin + ?
-
?

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
Mus musculus
Tissue-type plasminogen activator
-
Mus musculus
tPA
-
Mus musculus

General Information

General Information Comment Organism
physiological function despite its pro-fibrinolytic activity, tPA is a serine protease known to influence a number of physiological and pathological functions in the central nervous system. Accordingly, tPA mediates some of its functions in the central nervous system through N-methyl-D-aspartate receptors, low-density lipoprotein receptor-related protein, or annexin II. tPA can mediate proteolysis and subsequent delocalization of neuronal nitric oxide synthase, nNOS, thereby reducing endogenous neuronal nitric oxide release, independent of NMDA receptors, calpains, and low-density lipoprotein receptor-related proteins. tPA promotes proteolysis of nNOS through a plasmin-dependent mechanism, which is prevented in the presence of aprotinin and alpha2-antiplasmin, two blockers of the proteolytic activity of plasmin, overview Mus musculus