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Literature summary for 3.4.21.68 extracted from
- Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro: potential receptor interactions (2008), Thromb. Haemost., 100, 319-329.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HeLa cells and MCF-7 cells | synthetic construct |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| plasminogen activator inhibitor type 2 | can inhibit cell-bound tPA activity in vitro and thus prevents plasmin formation. Plasminogen activator inhibitor type 2 prevents annexin II heterotetramer/tPA-mediated plasminogen activation by its classic serpin inhibitory activity rather than through competition with tPA/plasminogen for binding. It inhibits cell bound tPA-induced plasmin activity in both an annexin II heterotetramer-dependent and -independent manner | synthetic construct |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
synthetic construct | 9986 | - |
| membrane | - |
synthetic construct | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| synthetic construct | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | - |
synthetic construct | plasmin + ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| t-PA | - |
synthetic construct |
| Tissue plasminogen activator | - |
synthetic construct |
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Release 2023.1 (January 2023)
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