Literature summary for 3.4.21.68 extracted from

Luo, M.; Tao, P.; Li, J.; Zhou, S.; Guo, D.; Pan, Z.
Immunization with plasmid DNA encoding influenza A virus nucleoprotein fused to a tissue plasminogen activator signal sequence elicits strong immune responses and protection against H5N1 challenge in mice (2008), J. Virol. Methods, 154, 121-127.

Search for more literature for 3.4.21.68

Application

Application	Comment	Organism
medicine	vaccination with a nucleoprotein with a tPA signal sequence efficiently clears homologous H5N1 influenza virus in infected lungs and induces partial cross-protection against heterologous, highly pathogenic H5N1 strains in mice. IFN-gamma producing T cells are more efficiently induced and expanded in mice immunized with ptPAs/nucleoprotein vaccine	synthetic construct

Cloned(Commentary)

Cloned (Comment)	Organism
nucleoprotein derived from H5N1 influenza virus fused with a tPA signal sequence, amplified, digested with Hind III and XhoI, cloned into pVAX1 and transfected into Vero cells. 293T cells transiently transfected with ptPAs/nucleoprotein	synthetic construct

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	the fusion nucleoprotein with a tPA signal sequence	synthetic construct	5737	-

Organism

Organism	UniProt	Comment	Textmining
synthetic construct	-	-	-

Synonyms

Synonyms	Comment	Organism
Tissue plasminogen activator	-	synthetic construct
tPA	-	synthetic construct

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)