Application | Comment | Organism |
---|---|---|
additional information | tPA can act as a cytokine, executing its cytoprotective actions via activation of a survival signaling hierarchy in interstitial fibroblasts | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | compared with wild-type, apoptosis of interstitial myofibroblasts is increased in tPA-/- mice after obstructive injury | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | tPA is a survival factor that prevents renal interstitial fibroblasts (cell line NRK-49F) and myofibroblasts from apoptosis induced by staurosporine and oxidative stress through an LRP-1-, Erk1/2-, p90RSK-, and Bad-dependent mechanism. Antiapoptotic effect of tPA is independent of its protease activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tissue-type plasminogen activator | - |
Mus musculus |
Tissue-type plasminogen activator | - |
Homo sapiens |
tPA | - |
Mus musculus |
tPA | - |
Homo sapiens |