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Literature summary for 3.4.21.68 extracted from

  • Ma, Y.H.; Wu, S.Y.; Wu, T.; Chang, Y.J.; Hua, M.Y.; Chen, J.P.
    Magnetically targeted thrombolysis with recombinant tissue plasminogen activator bound to polyacrylic acid-coated nanoparticles (2009), Biomaterials, 30, 3343-3351.
    View publication on PubMed
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Application

Application Comment Organism
medicine working strategy for targeted delivery of recombinant tPA bound to magnetic nanoparticles with less than 20% of a regular dose under magnetic guidance, resulting in effective thrombolysis and restore of hemodynamics in the rat embolic model synthetic construct

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5
-
 S-2288TM recombinant tPA synthetic construct
4.1
-
 S-2288TM recombinant tPA bound to polyacrylic acid-coated magnetite synthetic construct

Organism

Organism UniProt Comment Textmining
synthetic construct
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 synthetic construct plasmin + ?
-
 ?
S-2288TM + H2O amidolytic activity of recombinant tPA bound to polyacrylic acid-coated magnetite is 87% of that of free recombinant tPA. Amidolytic activity of recombinant tPA immobilized on magnetic nanoparticles coated with dextran is only 11-24% of recombinant tPA bound to polyacrylic acid-coated magnetite synthetic construct ?
-
 ?

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
 synthetic construct
tPA
-
 synthetic construct