Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin-1alpha | increases mRNA and protein expression of tPA in a time- and dose-dependent manner. Maximal stimulation at 72 h and 100 U/ml | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | tPA generation in wound epidermis is at least partially controlled by changes in local interleukin-1alpha activity | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
transforming growth factor-beta1 | partially inhibits interleukin-1alpha induced expression of tPA mRNA in a dose-dependent manner, maximal inhibition at 60 ng/ml | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | present in keratinocytes at the leading edge of the wound | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Tissue plasminogen activator | - |
Mus musculus |
tPA | - |
Mus musculus |