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Literature summary for 3.4.21.68 extracted from

  • Shim, B.S.; Kang, B.H.; Hong, Y.K.; Kim, H.K.; Lee, I.H.; Lee, S.Y.; Lee, Y.J.; Lee, S.K.; Joe, Y.A.
    The kringle domain of tissue-type plasminogen activator inhibits in vivo tumor growth (2005), Biochem. Biophys. Res. Commun., 327, 1155-1162.
    View publication on PubMed
Search for more literature for 3.4.21.68

Application

Application Comment Organism
medicine the kringle domain of tissue-type plasminogen activator inhibits in vivo tumor growth by suppression of angiogenesis without interfering with fibrinolysis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli and Saccharomyces cerevisiae Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
19950
-
 monomer, kringle domain of tissue-type plasminogen activator, calculated from amino acid sequence Homo sapiens
21590
-
 monomer, kringle domain of tissue-type plasminogen activator, glycosylated, MALDI analysis Homo sapiens
23940
-
 monomer, kringle domain of tissue-type plasminogen activator, glycosylated, MALDI analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00750
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
DLD-1 cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
plasminogen + H2O 37°C, pH 7.6 Homo sapiens plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
t-PA
-
 Homo sapiens
Tissue-type plasminogen activator
-
 Homo sapiens