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Literature summary for 3.4.21.68 extracted from
- Plasminogen activation and regulation of pericellular proteolysis (1985), Biochim. Biophys. Acta, 823, 35-65.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Fibrin | enhances activity | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-1-Proteinase inhibitor | - |
Homo sapiens | |
| alpha-2-Antiplasmin | - |
Homo sapiens | |
| alpha-2-Macroglobulin | - |
Homo sapiens | |
| C1-inhibitor | - |
Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 70000 | - |
x * 70000, human, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | Homo sapiens | responsible for practically all vascular fibrinolysis through activation of plasminogen | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | glycosylated at three of the four potential glycosylation sites | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
| saliva | - |
Homo sapiens | - |
| seminal plasma | - |
Homo sapiens | - |
| tear | - |
Homo sapiens | - |
| urine | - |
Homo sapiens | - |
| uterus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | cleavage of an Arg-Val bond near the carboxy-terminal end | Homo sapiens | plasmin + ? | Glu-plasmin consists of two polypeptides, MW 25000 and 65000, linked together by two disulfide bonds | ? | |
| plasminogen + H2O | Glu-plasminogen is the native form of human plasminogen | Homo sapiens | plasmin + ? | Glu-plasmin consists of two polypeptides, MW 25000 and 65000, linked together by two disulfide bonds | ? | |
| plasminogen + H2O | responsible for practically all vascular fibrinolysis through activation of plasminogen | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 70000, human, SDS-PAGE | Homo sapiens |
| More | the single-chain PA may occur in inactive and active forms | Homo sapiens |
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