Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Fibrin | enhances activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Human plasminogen activator inhibitors | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00002 | - |
Glu-plasminogen | with fibrinogen activation | Homo sapiens | |
0.00016 | - |
Lys-plasminogen | with fibrinogen activation | Homo sapiens | |
0.019 | - |
Lys-plasminogen | without fibrin | Homo sapiens | |
0.065 | - |
Glu-plasminogen | without fibrin | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell line | transformed, carcinoma | Homo sapiens | - |
endothelium | of veins and arteries | Homo sapiens | - |
fibrosarcoma cell line | transformed | Homo sapiens | - |
HeLa cell | transformed cell line | Homo sapiens | - |
hepatoma cell line | transformed | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Glu-plasminogen is the native form of human plasminogen | Homo sapiens | plasmin + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | t-PA is secreted as a single chain precursor which is cleaved at Arg275-Ile276 to a disulfide-linked two-chain form | Homo sapiens |