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Literature summary for 3.4.21.68 extracted from

  • Gerard, R.D.; Meidell, R.S.
    Regulation of tissue plasminogen activator expression (1989), Annu. Rev. Physiol., 51, 245-262.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Fibrin enhances activity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Human plasminogen activator inhibitors
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00002
-
Glu-plasminogen with fibrinogen activation Homo sapiens
0.00016
-
Lys-plasminogen with fibrinogen activation Homo sapiens
0.019
-
Lys-plasminogen without fibrin Homo sapiens
0.065
-
Glu-plasminogen without fibrin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell line transformed, carcinoma Homo sapiens
-
endothelium of veins and arteries Homo sapiens
-
fibrosarcoma cell line transformed Homo sapiens
-
HeLa cell transformed cell line Homo sapiens
-
hepatoma cell line transformed Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O Glu-plasminogen is the native form of human plasminogen Homo sapiens plasmin + ?
-
?

Subunits

Subunits Comment Organism
More t-PA is secreted as a single chain precursor which is cleaved at Arg275-Ile276 to a disulfide-linked two-chain form Homo sapiens