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Literature summary for 3.4.21.62 extracted from

  • Vartapetian, A.B.; Tuzhikov, A.I.; Chichkova, N.V.; Taliansky, M.; Wolpert, T.J.
    A plant alternative to animal caspases: subtilisin-like proteases (2011), Cell Death Differ., 18, 1289-1297.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.62

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Solanum lycopersicum

Inhibitors

Inhibitors Comment Organism Structure
additional information aldehyde and fluoromethyketone (FMK)-based inhibitors inhibit SAS-1 and -2 reversibly and only CMK-based inhibitors irreversibly inhibit the enzyme Avena sativa

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Avena sativa
-
-
extracellular extracellular in healthy tissues, shifts to cytoplasm upon programmed cell death induction Nicotiana tabacum
-
-
extracellular extracellular in healthy tissues, shifts to cytoplasm upon programmed cell death induction Oryza sativa
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
74500
-
 MALDI-TOF Avena sativa
80000
-
 single polypeptide chain Nicotiana tabacum
80000
-
 single polypeptide chain Oryza sativa
84000
-
 SDS-PAGE Avena sativa

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
 Arabidopsis genome contains 56 subtilase genes
-
Avena sativa
-
-
-
Glycine max
-
-
-
Nicotiana tabacum
-
-
-
Oryza sativa
-
-
-
Solanum lycopersicum
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification expressed as pre-pro-proteins whose prodomains are autocatalytically processed Nicotiana tabacum
proteolytic modification expressed as pre-pro-proteins whose prodomains are autocatalytically processed Avena sativa
proteolytic modification expressed as pre-pro-proteins whose prodomains are autocatalytically processed Oryza sativa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information displays preference for cleavage after Glu Glycine max ?
-
 ?
additional information enzyme is able to hydrolyze a range of fluorogenic substrates, including AFC derivatives of VEID, VAD, YVAD, IETD, VDVAD and LEHD Nicotiana tabacum ?
-
 ?
additional information enzyme is able to hydrolyze a range of fluorogenic substrates, including AFC derivatives of VEID, VAD, YVAD, IETD, VDVAD and LEHD Oryza sativa ?
-
 ?

Synonyms

Synonyms Comment Organism
ALE1 subtilase
-
 Arabidopsis thaliana
C1 subtilase
-
 Glycine max
P69 subtilase
-
 Solanum lycopersicum
phytophase extensive homology to other plant subtilisin-like serine protease, phytaspase: a plant aspartate-specific protease Nicotiana tabacum
phytophase extensive homology to other plant subtilisin-like serine protease, phytaspase: a plant aspartate-specific protease Oryza sativa
S1P subtilase
-
 Arabidopsis thaliana
SAS-1 extensive homology to other plant subtilisin-like serine protease Avena sativa
saspase saspase: serine proteases exhibting aspase activity Avena sativa
SDD1 subtilase
-
 Arabidopsis thaliana
SISBT3 subtilase
-
 Solanum lycopersicum

General Information

General Information Comment Organism
physiological function acts extracellularly in the apoplast of stomatal precursor cells where it may be involved in the generation of signals responsible for stomata density regulation Arabidopsis thaliana
physiological function enzyme shows caspase specificity Nicotiana tabacum
physiological function enzyme shows caspase specificity Oryza sativa
physiological function implicated in fragmentation of the membrane-bound transcription factor AtbZIP1723 and precursors of pectin methylesterase and rapid alkalinization growth factor Arabidopsis thaliana
physiological function involved in proteolysis of the seed storage protein, beta-conglycinin Glycine max
physiological function pathogenesis related protein which is shown to be one of several subtilases that are specifically induced following pathogen infection. P69 is suggested to process a leucin-rich repeat cell wall protein in virus-infected tomato plants Solanum lycopersicum
physiological function some caspase-like activities are attributable to the plant subtilisin-like proteases, saspases and phytaspases. Enzyme hydrolyzes a range of tetrapeptide caspase substrates following the aspartate residue. Enzyme is implicated the proteolytic degradation of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) during biotic and abiotic programmed cell death Avena sativa
physiological function some caspase-like activities are attributable to the plant subtilisin-like proteases, saspases and phytaspases. Enzyme hydrolyzes a range of tetrapeptide caspase substrates following the aspartate residue. In response to death-inducing stimuli, phytaspase is shown to re-localize to the cell interior Nicotiana tabacum
physiological function some caspase-like activities are attributable to the plant subtilisin-like proteases, saspases and phytaspases. Enzyme hydrolyzes a range of tetrapeptide caspase substrates following the aspartate residue. In response to death-inducing stimuli, phytaspase is shown to re-localize to the cell interior Oryza sativa
physiological function the subtilase ALE1 is involved in the generation of peptide signals that are required for cuticle formation and epidermal differentiation during Arabidopsis embryo development Arabidopsis thaliana