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Literature summary for 3.4.21.5 extracted from

  • Landis, B.H.; Koehler, K.A.; Fenton II, J.W.
    Human thrombins. Group IA and IIA salt-dependent properties of alpha-thrombin (1981), J. Biol. Chem., 256, 4604-4610.
    View publication on PubMed

General Stability

General Stability Organism
autolytic degradation of alpha-thrombin to nonclotting beta-thrombins and gamma-thrombins is retarded by increasing concentrations of Li+, Cs+, K+, Rb+ chlorides Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0052
-
benzoyl-Arg ethyl ester 0.15 M KCl Homo sapiens
0.0056
-
benzoyl-Arg ethyl ester 0.15 M NaCl Homo sapiens
0.0057
-
benzoyl-Arg ethyl ester 0.15 M CsCl Homo sapiens
0.0063
-
tosyl-Arg methyl ester 0.15 M NaCl Homo sapiens
0.007
-
benzoyl-Arg ethyl ester 0.15 M NaNO3 Homo sapiens
0.0072
-
tosyl-Arg methyl ester 0.15 M NaNO3 Homo sapiens
0.0075
-
benzoyl-Arg methyl ester 0.15 M KCl Homo sapiens
0.0079
-
benzoyl-Arg ethyl ester 0.15 M CsNO3 Homo sapiens
0.0088
-
benzoyl-Arg methyl ester 0.15 M NaCl Homo sapiens
0.0122
-
tosyl-Arg methyl ester 0.15 M KCl Homo sapiens
0.0133
-
tosyl-Arg methyl ester 0.15 M CsNO3 Homo sapiens
0.0137
-
tosyl-Arg methyl ester 0.15 M RbCl Homo sapiens
0.0152
-
tosyl-Arg methyl ester 0.15 M CsCl Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibrinogen + H2O Homo sapiens clotting of fibrinogen ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-Arg ethyl ester + H2O
-
Homo sapiens benzoyl-Arg + ethanol
-
?
benzoyl-Arg methyl ester + H2O
-
Homo sapiens benzoyl-Arg + methanol
-
?
Fibrinogen + H2O clotting of fibrinogen Homo sapiens ?
-
?
tosyl-Arg ethyl ester + H2O
-
Homo sapiens tosyl-Arg + ethanol
-
?
Tosyl-Arg methyl ester + H2O
-
Homo sapiens Tosyl-Arg + methanol
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
with increasing salt concentrations, the thermal stability of the enzyme activity is improved by group Ia clorides in decreasing order: Na+, K+, Rb+, Cs+. For ionic strength below 3 M the stability is reduced by group IIa chlorides in increasoing order: Mg2+, Sr2+, Ba2+, Ca2+. If the ionic strenght is about 3 M, the stability changes only slightly in LiCl or NaNO3 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.27
-
tosyl-Arg ethyl ester 0.15 M NaCl Homo sapiens
3.78
-
tosyl-Arg ethyl ester 0.15 M NaNO3 Homo sapiens
9.33
-
tosyl-Arg ethyl ester 0.15 M RbCl Homo sapiens
9.4
-
tosyl-Arg ethyl ester 0.15 M KCl Homo sapiens
10
-
tosyl-Arg ethyl ester 0.15 M CsNO3 Homo sapiens
10.3
-
tosyl-Arg ethyl ester 0.15 M CsCl Homo sapiens
13.7
-
benzoyl-Arg ethyl ester 0.15 M NaNO3 Homo sapiens
14
-
benzoyl-Arg methyl ester 0.15 M NaCl Homo sapiens
14.1
-
benzoyl-Arg ethyl ester 0.15 M NaCl Homo sapiens
15
-
benzoyl-Arg methyl ester 0.15 M KCl Homo sapiens
15.2
-
benzoyl-Arg ethyl ester 0.15 M KCl Homo sapiens
16.1
-
benzoyl-Arg ethyl ester 0.15 M CsCl Homo sapiens
17.8
-
benzoyl-Arg ethyl ester 0.15 M CsNO3 Homo sapiens