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Literature summary for 3.4.21.5 extracted from

  • Hsu, C.L.; Chang, H.T.; Chen, C.T.; Wei, S.C.; Shiang, Y.C.; Huang, C.C.
    Highly efficient control of thrombin activity by multivalent nanoparticles (2011), Chemistry, 17, 10994-11000.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
15-TBA15/TBA29/sulf-Gal-AuNPs most effective conjugated gold nanoparticle constructed with 15 thrombin-binding aptamers, comprising TBA15 and 15 TBA29 molecules, per AuNP. These exhibit, because of their particularly flexible conformation and multivalency, an ultrahigh binding affinity toward thrombin and thus extremely high anticoagulant/inhibitory potency Homo sapiens
additional information incorporation of sulfated galactose acid into thrombin-binding aptamer-conjugated gold nanoparticles, TBA-AuNPs, increases the inhibitory potency against thrombin, method development and evaluation, overview. Usage of 15mer and 29mer aptamers and 13 nm gold particles. Reversible binding reaction Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
fibrin + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
Homo sapiens fibrin + ?
-
?

Synonyms

Synonyms Comment Organism
alpha-thrombin
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens