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Literature summary for 3.4.21.5 extracted from
- Thrombin activation of PI3K/PDK1/Akt signaling promotes cyclin D1 upregulation and RPE cell proliferation (2011), Biochim. Biophys. Acta, 1813, 1758-1766.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Hirudin | - |
Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Long Evans rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Rattus norvegicus | - |
| retinal pigment epithelium | - |
Rattus norvegicus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | thrombin activates the PI3K/PDK1/Akt signaling, stimulating Akt Ser473, not Thr308, phosphorylation, which promotes cyclin D1 upregulation and RPE cell proliferation, overview. Thrombin proteolytic activation of protease-activated G protein coupled receptor-1 (PAR-1) activates PI3K and Akt. Thrombin-induced Akt stimulation promotes cyclin D1 accumulation through the phosphorylation/inhibition of GSK-3beta, thus preventing Thr286 cyclin D1 phosphorylation, nuclear export and degradation | Rattus norvegicus |
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