Activating Compound | Comment | Organism | Structure |
---|---|---|---|
D-glucose | high glucose enhances thrombin responses through transcriptional upregulation of protease-activated receptor-4, PAR-4, mediated via PKC-beta, -delta, and NFkappaB, in human vascular smooth muscle cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
vascular smooth muscle cell | - |
Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enhancement of thrombin-stimulated migration and gene expression by high glucose, which can be abolished by endogenous protease-activated receptor-4, PAR-4, knockdown | up |
General Information | Comment | Organism |
---|---|---|
malfunction | high glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, which may play an important role in the vascular complications of diabetes | Homo sapiens |
physiological function | thrombin evokes Ca2+ signaling in smooth muscle cell and induces smooth muscle cell migration and tumor necrosis factor alpha gene expression | Homo sapiens |