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Literature summary for 3.4.21.5 extracted from

  • Osipov, A.V.; Filkin, S.Y.; Makarova, Y.V.; Tsetlin, V.I.; Utkin, Y.N.
    A new type of thrombin inhibitor, noncytotoxic phospholipase A2, from the Naja haje cobra venom (2010), Toxicon, 55, 186-194.
    View publication on PubMed
Search for more literature for 3.4.21.5

Inhibitors

Inhibitors Comment Organism Structure
thrombin inhibitor from Naja haje thrombin inhibitor from Naja haje is a noncytotoxic phospholipase A2, mixed-type inhibitor of thrombin, inhibits the fibrinogenolytic and amidolytic activities of thrombin as well as its ability to induce platelet aggregation, it does not hydrolyze thrombin Bos taurus
thrombin inhibitor from Naja haje thrombin inhibitor from Naja haje is a noncytotoxic phospholipase A2, mixed-type inhibitor of thrombin, inhibits the fibrinogenolytic and amidolytic activities of thrombin as well as its ability to induce platelet aggregation, it does not hydrolyze thrombin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
 fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?
fibrinogen + H2O Bos taurus
-
 fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
 Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?
fibrinogen + H2O
-
 Bos taurus fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?
N-(4-tosyl)-Gly-L-Pro-L-Arg-4-nitroanilide + H2O
-
 Bos taurus N-(4-tosyl)-Gly-L-Pro-L-Arg + 4-nitroaniline
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000728
-
 thrombin inhibitor from Naja haje in 10 mM imidazole buffer (pH 7.4), at 37°C Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000002
-
 in 10 mM imidazole buffer (pH 7.4), at 37°C Bos taurus thrombin inhibitor from Naja haje