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Literature summary for 3.4.21.5 extracted from

  • Robert, S.; Ghiotto, J.; Pirotte, B.; David, J.L.; Masereel, B.; Pochet, L.; Dogne, J.M.
    Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs? (2009), Pharmacol. Res., 59, 160-166.
    View publication on PubMed
Search for more literature for 3.4.21.5

Activating Compound

Activating Compound Comment Organism Structure
factor Xa
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
argatroban competitive thrombin inhibitor Homo sapiens
enoxaparin
-
 Homo sapiens
H-D-Phe-Pro-Arg-chloromethylketone irreversible thrombin inhibitor Homo sapiens
Hirudin tight-binding thrombin inhibitor Homo sapiens
lepirudin a recombinant form of hirudin Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for thrombin activation by factor Xa Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
 fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
 Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?