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Literature summary for 3.4.21.5 extracted from
- Inhibition of thrombin formation by active site Ser360 to Ala-substituted activated protein C (2010), J. Biol. Chem., 30, 22890-22900.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibrinogen + H2O | Bos taurus | - |
fibrin + fibrinopeptide A + fibrinopeptide B | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibrinogen + H2O | - |
Bos taurus | fibrin + fibrinopeptide A + fibrinopeptide B | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-thrombin | - |
Bos taurus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Bos taurus | activated protein C down-regulates thrombin formation through proteolytic inactivation of factor Va by cleavage at Arg506 and Arg306 and of factor VIIIa by cleavage at Arg336 and Arg562 | down |
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Release 2023.1 (January 2023)
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