Literature summary for 3.4.21.5 extracted from

Numakura, M.; Kusakabe, N.; Ishige, K.; Ohtake-Niimi, S.; Habuchi, H.; Habuchi, O.
Preparation of chondroitin sulfate libraries containing disulfated disaccharide units and inhibition of thrombin by these chondroitin sulfates (2010), Glycoconj. J., 27, 479-489.

Search for more literature for 3.4.21.5

Inhibitors

Inhibitors	Comment	Organism	Structure
antithrombin	-	Bos taurus
glycosaminoglycan AD17	-	Bos taurus
glycosaminoglycan AD4	shows only small inhibitory activity toward thrombin and the inhibition does not proceed beyond 40% inhibition	Bos taurus
glycosaminoglycan AD9	shows only small inhibitory activity toward thrombin and the inhibition does not proceed beyond 40% inhibition	Bos taurus
glycosaminoglycan AE11	modest inhibitory effect on thrombin activity	Bos taurus
glycosaminoglycan AE15	-	Bos taurus
glycosaminoglycan AE29	-	Bos taurus
glycosaminoglycan AE6	modest inhibitory effect on thrombin activity	Bos taurus
glycosaminoglycan CS-D	-	Bos taurus
glycosaminoglycan CS-E	-	Bos taurus
glycosaminoglycan DE17	-	Bos taurus
glycosaminoglycan DE2	-	Bos taurus
glycosaminoglycan DE9	-	Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
fibrinogen + H2O	Bos taurus	-	fibrin + fibrinopeptide A + fibrinopeptide B	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
fibrinogen + H2O	-	Bos taurus	fibrin + fibrinopeptide A + fibrinopeptide B	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0001	-	-	Bos taurus	glycosaminoglycan CS-E
0.00015	-	-	Bos taurus	glycosaminoglycan DE17
0.00025	-	-	Bos taurus	glycosaminoglycan DE9
0.00055	-	-	Bos taurus	glycosaminoglycan DE2
0.0007	-	-	Bos taurus	glycosaminoglycan AD17
0.00092	-	-	Bos taurus	glycosaminoglycan AE29
0.00095	-	-	Bos taurus	glycosaminoglycan CS-D
0.0025	-	-	Bos taurus	glycosaminoglycan AE15
0.00429	-	IC50 above 0.00429 mM	Bos taurus	glycosaminoglycan AE6
0.00429	-	IC50 above 0.00429 mM	Bos taurus	glycosaminoglycan AE11
0.00429	-	IC50 above 0.00429 mM	Bos taurus	glycosaminoglycan AD4
0.00429	-	IC50 above 0.00429 mM	Bos taurus	glycosaminoglycan AD9

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Release 2023.1 (January 2023)