Literature summary for 3.4.21.5 extracted from

Chung, S.W.; Park, J.W.; Lee, S.A.; Eo, S.K.; Kim, K.
Thrombin promotes proinflammatory phenotype in human vascular smooth muscle cell (2010), Biochem. Biophys. Res. Commun., 396, 748-754.

Search for more literature for 3.4.21.5

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	thrombin-mediated expression of interleukin-6 and CXCL8 is significantly inhibited by LY294002, AKT IV, RO318220, and GF109203X as well as by diphenyleneiodium at the messenger RNA and the protein levels. SB202129 and U0126 also significantly attenuate thrombin-mediated release of interleukin-6 and CXCL8 proteins from human aortic smooth muscle cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	thrombin elevates transcripts for interleukin-6, CXCL8, and CCL11 genes and also enhances release of interleukin-6 and CXCL8 protein from human aortic smooth muscle cell, thrombin promotes proinflammatory phenotype in human vascular smooth muscle cell	Homo sapiens

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Release 2023.1 (January 2023)