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Literature summary for 3.4.21.5 extracted from
- Mechanism of thrombin inhibition by heparin cofactor II and antithrombin in the presence of the ray (Raja radula) skin dermatan sulfate (2009), Thromb. Res., 123, 902-908.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antithrombin | presence of dermatan sulfate increases the rate constant for inhibition by forming a dermatan sulfate-antithrombin complex more reactive than free antithrombin towards thrombin | Homo sapiens | |
| dermatan sulfate | isolated from skin of Raja radula, in presence of heparin cofactor II or antithrombin. Dermatan sulfate from ray skin catalyzes the thrombin inhibition by heparin cofactor II or antithrombin primarily by forming a dermatan sulfate-inhibitor complex more reactive than the free inhibitor towards the protease | Homo sapiens |  |
| heparin cofactor II | presence of dermatan sulfate increases the rate constant for inhibition by forming a dermatan sulfate-heparin cofactor II complex more reactive than free heparin cofactor II towards thrombin | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
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Release 2023.1 (January 2023)
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