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Literature summary for 3.4.21.5 extracted from

  • Pineda, A.O.; Zhang, E.; Guinto, E.R.; Savvides, S.N.; Tulinsky, A.; Di Cera, E.
    Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form (2004), Biophys. Chem., 112, 253-256.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
mutant D221A/D222K bound with a fragment of hirudin, slight collapse of the 186 and 220 loops into the Na+ bindung site. Crucial role of D221/D187 ion pair in stabilizing the Β“fastΒ” form of enzyme Homo sapiens

Protein Variants

Protein Variants Comment Organism
D221A/D222K no binding of Na+, crystallization data Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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